THE 2-MINUTE RULE FOR GR

The BclI GR polymorphism comprises a C to G nucleotide substitution at 646 bp downstream of exon 2 in intron B of the human GR gene that results in a chopping web-site for that BclI restriction enzyme. G-allele of the polymorphism improves tissue sensitivity to glucocorticoids as revealed by greater suppression of serum cortisol concentrations